The Potential Use of Plant-Derived Compounds in Glioblastoma Management

Glioblastoma or glioblastoma multiform (GBM), is recognized as the most frequent and malignant nervous system tumor. Conventional therapeutic strategies, such as surgical resection and chemo-radiotherapy, have done very little in prolonging the survival time of GBM patients. The difficulties in human GBM therapy are due to the inherently complicated pathological characteristic and numerous drug-resistance mechanisms. For this reason, more efficient therapeutic approaches are required for enhancing the treatment effect. One of the most attractive cancer therapy methods to date is the induction of tumor cell death by naturally occurring phytochemicals. In this chapter, we mainly summarize the most up-to-date findings regarding the representative plant-derived compounds that play important roles in the GBM treatment. Additionally, the applicability of phytochemical-loaded nanoparticles (NPs) as drug delivery systems (DDS) should also be closely considered and further investigated.